Globally, CVD is the leading cause of death, posing significant health and economic burdens. Cardiovascular diseases (CVDs), including hypertension, coronary artery disease (CAD), and hypertensive heart disease (HHD), are leading causes of morbidity and mortality globally. The primary challenges in combating CVD include the early detection and management of risk factors such as hypertension, obesity, diabetes, high cholesterol, lifestyle factors like poor diet, physical inactivity, smoking, and genetic predispositions. Addressing these challenges requires comprehensive strategies focusing on prevention, early diagnosis, and personalized treatment approaches. 

In Indonesia, the prevalence of cardiovascular diseases is rising, driven by demographic shifts, lifestyle changes, and increasing rates of risk factors such as hypertension, diabetes, and obesity. The burden of CVD in Indonesia reflects a growing public health concern, with a significant impact on mortality, morbidity, and healthcare costs.

Clinico-genomic research, which integrates clinical data with genomic insights, offers a promising avenue for advancing cardiovascular disease management in Indonesia. By identifying genetic markers and variants associated with increased risk of CVD, our clinico-genomic research could facilitate personalized medicine, identify high-risk individuals, guide drug development, enhance prevention strategy, and predict disease progression.